A protein stability engine built for protein engineers
No structural biology degree required. Paste a sequence, define a mutation panel, and get ranked stability predictions in under a minute.
From FASTA to ranked shortlist
Upload a single FASTA or a batch of sequences. The platform runs saturation mutagenesis scanning, combinatorial panels, or a custom list of specific variants depending on your campaign needs.
- Single-point saturation scan across all 20 amino acids per position
- Multi-site combinatorial panels with epistatic coupling scores
- CSV export with variant ID, mutation list, dG prediction, and stability class
Stability heatmap: see every position at a glance
The interactive stability heatmap plots predicted dG across positions and substitutions. Identify hotspot positions, beneficial mutation clusters, and regions to avoid before ordering oligos.
- Color-coded delta-G grid: beneficial (teal) to destabilizing (red)
- Click any cell to view the full variant scoring report
- Export heatmap as PNG or underlying data as TSV
Fits into the workflows you already use
Access Scala through the web interface, the REST API, or the Python client library. No new toolchain to learn.
Web interface
Log in, upload a sequence, configure your scan, and download results without writing a single line of code.
REST API
Submit jobs, poll status, and retrieve results programmatically. JSON in, JSON out. OpenAPI spec included.
Python client
The scalabd package wraps the API and returns pandas DataFrames for direct integration with your analysis notebooks.
Ready to run your first variant panel?
Early-access seats are limited. Request yours and get onboarded within 48 hours.